Faculty Members

Note: Students funded by the RNA Innovation CREATE program do not have to be supervised or co-supervised by a co-applicant.

University of Lethbridge Co-Applicants

HJ WiedenPhysical biochemistry, Rapid kinetics, Protein biosynthesis, Antibiotics, Ribosome function, Bioinformatics, Cryo-electron microscopy, Molecular modeling, RNA, Fluorescence spectroscopy, In vitro translationNovel translation factors, Molecular dynamics of translation, Kinetics of translation, Antibiotic (mode of action), In vitro translation, assay development, Synthetic biology
Marc RousselChemical kinetics, Model reduction, Nonlinear dynamics, Mathematical biologyModel reduction, Model equivalence, Dynamic modeling, Chemical oscillations, Nonlinear dynamics, Microbial modeling, Reaction-diffusion systems, Stochastic kinetics, Transcription
Ute KotheRNA, Protein, Ribonucleoprotein, Rapid kinetics, Fluorescence spectroscopy, Crosslinking, Primer extension analysis, Immuno blotting, Chromatography, Ultracentrifugation, Electrophoresis, Molecular cloning, Mutagenesis;yeast geneticsH/ACA small ribonucleoproteins, Ribosome biogenesis, RNA modification, Pseudouridine, RNA-protein interactions, Dyskeratosis congenita
Athanasios ZovoilisDissecting the role of non-coding RNAs in cellular response to stress, identifying disease aassociated non-coding RNAs and developing genome interpretation algorithms for cancer and dementia, exploiting genome intelligence for IT purposes
Olga KovalchukRole of epigenetic dysregulation in carcinogenesis, Epigenetic regulation of the cancer treatment responses, Radiation epigenetics and role of epigenetic changes in genome stability and carcinogenesis, Radiation-induced oncogenic signaling, Radiation-induced DNA damage, repair and recombination
Nehal ThakorCell Biology, Gene expression under stress conditions, Apoptosis, Mechanisms of cancer cell survival, Regulation of mRNA translation, Angiogenesis in cancer progression, Brain Tumor Stem Cells (BTSCs), Live cell imaging and fluorescence microscopy, Lentiviral vectors, Polysome profiling, Ribosome Profiling, Metabolic engineering, RNA elements, Internal Ribosome Entry Sites (IRESes), Riboswitch, ThermoswithRole of eukaryotic initiation factors (eIFs) in cellular stress, apoptosis, and cancer progression
Role of eIF5B in the survival, angiongensis, and progression of Head and Neck Squamous Cell Carcinoma (HNSCC)
Regulation of mRNA translation by eIF5B in glioblastoma
Non-canonical transition in cellular stress and apoptosis
IRES-mediated translation of mRNAs encoding anti-apoptotic proteins under stress conditions
Role of PDCD4 in IRES-mediated translation
Microbial metabolic engineering using RNA elements for the production of value-added goods
Employing riboswitches and ribo-attenuators for the production of biofuels in industry relevant bacteria
Understanding the biological functions of thermoswitches and their applications in biotechnology
Stacey WetmoreComputational chemistry, Molecular modeling, ab initio methods, Density functional theory, Molecular dynamics simulations, QM/MM techniques, Electronic structure and properties, Reaction mechanisms, DNA, RNA, Nucleic acid–enzyme interactions, Enzyme functionModified DNA structure and function, Damaged DNA replication, Damaged DNA repair, Impact of RNA modifications, Ribozyme function, Design of Nucleic acid aptamers, Impact of Heavy metal contamination

Université de Sherbrooke Co-Applicants

Michelle ScottTranscriptomics, small non-coding RNAs, regulation of gene expression, cellular localization of proteins, always using bioinformatic approaches.Building analysis tools to accurately quantify non-coding RNAs and particularly those encoded in host gene introns and those present multiple times in the genome (eg snoRNA, snRNA).

RNA G-quadruplexes, structural elements regulating the transcriptome;

Built a web tool for the visualization of the regulation of the inclusion of protein and patterns by alternative splicing;

Characterize the binding profiles of RNA-binding proteins (RBPs) on transcripts and their regulatory effects;

We are interested in improving and customizing the transcriptome annotations to ensure accurate quantification of gene expression.

The tools and methodologies we propose to improve the quantification of transcriptomic data and a better understanding of the transcriptome and of gene expression.
Jean-Pierre PerreaultExpert in the design of gene inactivation systems based on the use of nucleic acids (antisense technology, siRNA and ribozyme).
Co-holder of several patents of ribozyme technology.
Specialist in molecular engineering and RNA enzymology.
My team studies structures in mRNAs that help regulate their translation into proteins. We are particularly interested in mRNAs associated with cancer development. Additionally, we are also studying viroids, single-stranded RNA causing several diseases. The realization of this research will answer fundamental questions in the fields of molecular biology, genetics, structural biochemistry as well as molecular evolution and virology. Our lab hopes to identify the most important RNA motifs and then target them with chemical compounds and thus control their formation and thereby the development of associated pathologies.
Sherif Abou ElelaMember of the oncology research group of the Étienne-Le Bel Clinical Research Center of CHUS and the RNA group. He is also Scientific Director of the Functional Genomics Laboratory of Sherbrooke and the RNomics Platform.To understand the basic mechanism that leads to the formation and maintenance of double-stranded RNAs and to identify the cellular components that regulate this activity. This work will not only have an impact on the understanding of the mechanism of degradation of messenger RNAs, but also on that of gene regulation in general.
Francois BachandMolecular genetics
Study of gene expression
Use of genomics and proteomics approaches
To better understand how gene expression is controlled in normal and cancerous cells, my laboratory focuses on two distinct aspects of post-transcriptional gene regulation. On the one hand, we are studying the role of different cytoplasmic and nuclear proteins linking the poly (A) tail of RNA in the control of gene expression. On the other hand, my lab is studying how post-translational modifications, particularly arginine methylation, modulate the function of various RNA-binding proteins. Our research group uses the most advanced methods in molecular biology, genomics and proteomics to answer these questions. This research could lead to the discovery of new targets for the treatment of several diseases.